Exelixis closed King of Prussia facility and cut 130 jobs, including 33 remote roles

Exelixis laid off 130 employees companywide in August 2025 when it closed its King of Prussia, Pennsylvania facility, a reduction that included 33 remote employees who reported to California-based managers. The company had hired many remote workers during and after the COVID-19 pandemic and said it was restructuring to concentrate largely on its Alameda, California operations, with expectations to reopen many affected roles as on-site positions at its Alameda headquarters. The cuts were tied to a facility closure and operational consolidation rather than solely performance, and return-to-office decisions were cited as a factor for some remote workers. The article places Exelixis's reduction in the broader industry context of employers favoring on-site or hybrid work to promote collaboration.

Exelixis, Inc. cut 130 jobs in PA as of August 29, 2025.

That is roughly 21.7% of the 600 people Exelixis, Inc. employs.

LayoffTalk has tracked 5 layoff events at Exelixis, Inc. since March 2024, including 288 jobs documented in official WARN filings, with 2 additional events known from news reporting.