Replimune Layoff — April 2026
SOURCEOFFICIAL FILINGMassachusetts Executive Office of Labor and Workforce Development· filed April 17, 2026View the filing ↗
What we know
Location: Framingham, MA · 2 locations.
A WARN notice for this layoff is recorded on April 17, 2026.
Disclosed through an official WARN filing with the MA state workforce agency.
Summary
Replimune Group, Inc. filed a WARN notice saying it will lay off 63 employees at its Woburn location, with the cuts scheduled to occur between April 13 and April 24. The layoffs follow the FDA's April 10 complete response letter rejecting Replimune's biologics license application for its lead investigational cancer therapy RP1 (vusolimogene oderparepvec), the company's second regulatory rejection after a July 2025 refusal. CEO Sushil Patel said the company must eliminate jobs and substantially scale back U.S.-based manufacturing operations, and Replimune is exploring strategic alternatives. The WARN filing lists Woburn as the affected site and it is unclear whether additional layoffs beyond the 63 are planned.
Replimune disclosed this layoff in an official WARN (Worker Adjustment and Retraining Notification) notice recorded by the MA state workforce agency on April 17, 2026. The notice covers 161 employees in Framingham, MA, with the layoff effective April 17, 2026.
The state lists each affected employee separately by work location, so this filing spans 2 MA communities: Framingham, Woburn.
LayoffTalk has tracked 3 layoff events at Replimune since April 2026, including 224 jobs documented in official WARN filings, with 1 additional event known from news reporting.
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