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REPORTED · NEWSAdded Dec 24, 2025

Alector LLC Halves Staff Following Phase 3 Trial Failure

SOURCENews reportView the filing ↗

EFFECTIVE DATE
Oct 22, 2025

What we know

Location: San Francisco, California, USA.

Based on news reporting.

Summary

Alector LLC has announced significant layoffs, cutting its workforce by half, which equates to approximately 50 employees. This decision follows the disappointing results of a Phase 3 clinical trial for an antibody developed in partnership with GSK aimed at treating dementia. The company is now focusing on its remaining programs and streamlining operations in light of the trial's failure. The layoffs are part of a broader effort to adjust to the challenges faced in the biotech sector, particularly in the development of new therapies. Alector's headquarters is located in San Francisco, California.

LayoffTalk has tracked 4 layoff events at Alector LLC since March 2025, including 75 jobs documented in official WARN filings, with 3 additional events known from news reporting.

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SOURCE
News reporting
View original source ↗
A
Alector LLCALEC
Health Care · 135 employees
4
EVENTS TRACKED
75
JOBS IN WARN FILINGS
View company profile

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CREATED DEC 24, 2025LAST UPDATED AUG 27, 2026