City of Hope Layoff — November 2025

City of Hope, a Duarte-based national cancer care nonprofit, laid off roughly 200 workers this week — about 1.3% of its roughly 15,000-person workforce — marking its first staff reductions since 1997. Most affected employees were in business support and operations teams across levels, including management, and City of Hope stated the reductions do not directly impact patient care. Laid-off staff were notified on Thursday and the nonprofit is offering transition pay, severance, benefits, outplacement and other support services. Leadership said the cuts align resources with strategic priorities amid economic headwinds and policy changes while the system continues major expansion in Orange County, including a nearly completed $452 million dedicated cancer hospital in Irvine.

City of Hope disclosed this layoff in an official WARN (Worker Adjustment and Retraining Notification) notice recorded by the CA state workforce agency on September 25, 2025. The notice covers 196 employees in Rivergrade Road Baldwin Park, CA (Los Angeles County), with the layoff effective November 25, 2025.

The state lists each affected employee separately by work location, so this filing spans 2 CA communities: Duarte Road Duarte, Rivergrade Road Baldwin Park.

That is roughly 3.9% of the 5,000 people City of Hope employs.

LayoffTalk has tracked 2 layoff events at City of Hope since September 2025, including 196 jobs documented in official WARN filings, with 1 additional event known from news reporting.