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REPORTED · WARN NOTICEPublished Dec 10, 2025

Sutro Biopharma, Inc. Layoff — September 2025

EMPLOYEES AFFECTED
45
SHARE OF WORKFORCE
~45%
EFFECTIVE DATE
Sep 30, 2025
45 OF 100 EMPLOYEES

What we know

Location: Oyster Point Blvd South San Francisco, CA (San Mateo County).

A WARN notice was filed on September 29, 2025.

Disclosed through an official WARN filing with the CA state workforce agency.

Summary

Sutro Biopharma, Inc. is making deeper cuts to extend its financial runway into 2027 and to reach key data readouts. Specific details regarding the number of employees affected by these cuts were not disclosed.

Sutro Biopharma, Inc. disclosed this layoff in an official WARN (Worker Adjustment and Retraining Notification) notice filed with the CA state workforce agency on September 29, 2025. The notice covers 45 employees in Oyster Point Blvd South San Francisco, CA (San Mateo County), with the layoff effective September 30, 2025.

That is roughly 45% of the 100 people Sutro Biopharma, Inc. employs.

LayoffTalk has tracked 7 layoff events at Sutro Biopharma, Inc. since October 2023, affecting a combined 340 employees.

Comments (1)

Anonymous by default. Be kind — people reading this may be going through it right now.

LTLayoffTalk StaffStaff22 hours ago

Sutro Biopharma, Inc. cut 45 jobs in Oyster Point Blvd South San Francisco, CA on September 30, 2025. Were you affected, or do you know people who were? How was it handled — severance, notice, which teams? You can post anonymously below.

SOURCE
Official WARN notice
View state filing ↗
S
Sutro Biopharma, Inc.STRO
Health Care · 100 employees
7
EVENTS TRACKED
340
AFFECTED SINCE 2023
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CREATED DEC 10, 2025LAST UPDATED DEC 30, 2025