Genentech, Inc. Layoff — November 2025
SOURCEOFFICIAL FILINGCalifornia Employment Development Department· filed October 24, 2025View the filing ↗
What we know
Location: South San Francisco, California, USA (San Mateo County).
A WARN notice for this layoff is recorded on October 24, 2025.
Disclosed through an official WARN filing with the CA state workforce agency.
Summary
Genentech, a subsidiary of Roche, has laid off 118 employees at its headquarters in South San Francisco, marking the third round of layoffs this year. This decision reflects ongoing restructuring efforts within the company as it adapts to changing market conditions. The layoffs are part of a broader strategy to streamline operations and improve efficiency. Genentech has faced challenges in recent months, prompting these workforce reductions to align with its business objectives. The company aims to maintain its competitive edge while navigating the evolving pharmaceutical landscape.
Genentech, Inc. disclosed this layoff in an official WARN (Worker Adjustment and Retraining Notification) notice recorded by the CA state workforce agency on October 24, 2025. The notice covers 118 employees in DNA Way South San Francisco, CA (San Mateo County), with the layoff effective November 28, 2025.
That is roughly 0.9% of the 13,000 people Genentech, Inc. employs.
LayoffTalk has tracked 13 layoff events at Genentech, Inc. since May 2023, including 1,392 jobs documented in official WARN filings, with 5 additional events known from news reporting.
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